L- Arginine deficiency has been estimated to occur in approximately 1 in 300,000-1,000,000 births.
L- Arginine deficiency is among the least common of all the disorders of the urea cycle. The expected frequency of urea cycle diseases collectively is one in 30,000.
However, because urea cycle dysfunctions like arginase deficiency often go unrecognized, these disorders are under-diagnosed, making it hard to determine the actual frequency of urea cycle disorders in the global population.
This is likely to change now that l arginine deficiency can be diagnosed by newborn screening.
What Are The Side Effects Of L- Arginine If It Is Taken In Overdose?
L- Arginine is an amino acid usually produced by the body in the amounts required for proper functioning. Most people do not require any more L- Arginine than what their bodies naturally supply.
Some want to supplement. In a few cases, it is possible to supplement too much and cause side effects to occur.
Some of the more frequent l arginine side effects.
- Airway Inflammation
- Low Blood Pressure
- Abdominal Pain
- Blood Abnormalities
- Worsening Of Asthma.
However, too much of L- Arginine may occur in a few serious difficulties that must be considered.
What Is The Impact of L- Arginine If It Is Taken During Smoking And Drinking?
L- Arginine is not suggested while you are smoking or drinking. If you have taken while smoking and drinking, it can result in a few problems.
Generally, smoking and drinking may lead to hypertension and stroke due to the reduced ability for the body to synthesize nitric oxide (NO). NO is a small molecule which has been implicated in a variety of physiological methods. One of its more significant functions includes the relaxation of blood vessels.
NO has been given to dilate blood vessels and thus, allow more blood to flow. The human body takes advantages of this system to regulate the amount of blood flow to different parts of the body by controlling the amount of NO produced.
NO is produced in the body by an enzyme called nitric oxide synthase (NOS). NOS generates NO from L- Arginine, one of the 20 essential amino acids. When NOS does not function properly, hypertension can happen since the blood vessels are more constricted.
Also, there is an enhanced chance of stroke because of these narrow vessels and thickening of the blood. It is by this process by which we understand that smoking can cause hypertension and strokes.
Other latest researchers have revealed that elements of cigarette smoke and alcohol can respond with l arginine powder to form an L- Arginine adduct. This effect may have two possible effects.
First, it may reduce the amount of L- Arginine in the body and thus, less NO is produced since there is less of its precursor. Furthermore, the adduct formed may bind to the NOS itself and inhibit its function.
Why Do People Take L- Arginine?
Because it eases blood vessels, L- Arginine might have cardiovascular benefits for some people. Few studies show that it might promote the symptoms of angina and peripheral arterial disease.
It seems to promote the health of people with heart failure. It might also assist with erectile dysfunction, but mostly when combined with other supplements such as Pycnogenol. Some latest studies have shown an immune-boosting effect.
L- Arginine may also combat the symptoms of weight loss caused by HIV. It seems to improve the signs of kidney inflammation and assists kidney function after a transplant. Studies show l arginine might ease migraines, increase blood pressure, and reduce healing time after surgery.
Not all studies have been positive. L- Arginine does not seem to help with heart attack rehabilitation, preeclampsia, wound healing, or exercise sensitivity in people with heart failure. It seems to worsen asthma.
Recommended Dosage, Active Amounts, Other Details
Dosage For Children
- Children 1-3 years: 3 mg/day
- Children 3-8 years: 6 mg/day
- Children 8-12 years: 11 mg/day
- Children 13-15 years: 17 mg/day.
The recommended dosage of L- Arginine varies depending on the treatment. For congestive heart failure, recommends doses ranging from 6 g to 20 g per day, which changes on a case-by-case basis.
For adults chest pain caused by clogged arteries, 28 g of L- Arginine is taken in equal increments three or four times daily. Men who have erectile dysfunction may benefit from 5 g of L- Arginine per day.
The standard pre-workout dose for L- Arginine is 3-6g.
To control elevated L- Arginine levels during the day, L- Arginine can be taken up to three times a day. Note: L-Citrulline supplementation with L- Arginine is more efficient at managing high L- Arginine levels for long periods of time.
Drug Interactions And Supplement Interactions
Below are Possible interactions include:
- Anticoagulants and antiplatelet drugs, herbs and supplements. These types of medicines, herbs, and supplements reduce blood clotting. Taking L- Arginine with them might improve the risk of bleeding.
- Blood pressure drugs, herbs, and supplements. L- Arginine might decrease blood pressure in people who have high blood pressure. Combining the use of L- Arginine with a blood pressure drug, herb or supplement might improve the risk of blood pressure becoming too low.
- Diabetes drugs, herbs, and supplements. L- Arginine might reduce blood sugar levels in people who are with diabetes. If you’re using diabetes drugs, herbs or supplements, your dosage might require to be adjusted.
- Isoproterenol. Use of this heart medication with a combination of L- Arginine might cause your blood pressure to become too low.
- Nitrates. Use of this chest pain medication with the L- Arginine might cause your blood pressure to become too low.
- Water pills (potassium-sparing diuretics). Don’t consume amiloride (Midamor), spironolactone (Aldactone) or triamterene (Dyrenium) with L- Arginine. These medications can improve potassium levels, enhancing the risk of developing a higher than normal level of potassium in your blood (hyperkalemia).
- Sildenafil (Viagra). Using this erectile dysfunction medication with L- Arginine might cause your blood pressure to become too low.
This information carries all possible interactions or adverse effects. Therefore, before utilizing this product, tell your doctor or pharmacist of all the products you utilize. Keep a list of all your medications with you, and share this knowledge with your doctor and also with your pharmacist.
Check with your health care professional or with the doctor for further medical advice, or if you have health issues, concerns or for more information about this medicine.